Mysimba (naltrexone / bupropion) – Weight Loss Treatment

What is Mysimba?

Mysimba is a prescription weight loss treatment taken as tablets, used to support weight management in suitable adults.
It contains a combination of naltrexone and bupropion and is supplied following a clinical assessment.

Treatment is intended to be used alongside lifestyle measures such as diet and physical activity, as part of a structured weight management approach.

How does Mysimba work?

Mysimba works by acting on areas of the brain involved in appetite control, food cravings, and reward pathways.

By influencing these pathways, Mysimba can help reduce hunger and support better control over eating behaviours.

• Helps reduce hunger and food cravings
• Acts on brain pathways involved in eating behaviour
• Supports improved control over food intake

These effects can help support weight loss when combined with lifestyle changes.

What results can be expected?

In clinical studies, Mysimba has been shown to support weight loss when combined with diet and lifestyle changes.

• Average weight loss of around 3–6% has been reported in studies
• Results tend to build gradually over time
• Individual results vary depending on adherence and lifestyle factors

How is Mysimba used?

Mysimba is taken as tablets, with the dose increased gradually over the first few weeks.

• Taken daily in divided doses
• Dose is increased gradually to improve tolerability
• Should be taken as directed by your prescriber

You will be advised on how to take the medication safely and how the dosing schedule works.

Who may be suitable for Mysimba?

Mysimba may be considered for adults seeking a tablet-based weight management option, where clinically appropriate.

• Body weight and BMI
• Medical history
• Current medications
• Eating patterns and lifestyle factors

A clinician will assess whether this treatment is appropriate for you.

Important information before starting treatment

Mysimba is not suitable for everyone.

• Have certain neurological or psychiatric conditions
• Have uncontrolled high blood pressure
• Are taking medications that may interact

A full clinical assessment is required before supply.

Side effects and monitoring

Like all medicines, Mysimba can cause side effects.

• Nausea
• Headache
• Insomnia
• Dizziness

These side effects are often more noticeable when starting treatment and may improve over time.
Ongoing monitoring may be recommended to ensure treatment remains appropriate.

Ongoing treatment and support

Mysimba is typically used as part of a longer-term weight management plan alongside lifestyle changes.

• Regular follow-up
• Monitoring of progress and tolerability
• Support with eating behaviours and lifestyle changes

Maintaining consistent use and lifestyle changes is important for achieving the best results.