Mysimba 8 mg/90 mg tablets

MySimba® is a prescription-only weight loss treatment containing a combination of naltrexone hydrochloride and bupropion hydrochloride. It is a prolonged-release tablet used to support weight management in adults who meet the appropriate prescribing criteria.

Unlike injectable weight loss treatments, MySimba® is taken orally as a tablet and works by targeting areas of the brain involved in appetite control, food cravings and eating behaviour.

At The Kingston Pharmacy, MySimba® is supplied as part of our clinician-led weight loss service following a suitability assessment by our clinicians.

Available Strengths

MySimba® prolonged-release tablets contain:

• 8mg naltrexone hydrochloride
• 90mg bupropion hydrochloride

Treatment is started at a lower dose and gradually increased over several weeks until the recommended maintenance dose is reached.

Our clinicians will determine the most appropriate dosing schedule based on your individual treatment plan.

How Does MySimba® Work?

MySimba® contains two active ingredients, naltrexone and bupropion, which work together on areas of the brain involved in appetite regulation, reward and food cravings.

By acting on these pathways, MySimba® can help reduce hunger, improve control over eating habits and decrease cravings for food. This may make it easier to reduce calorie intake and maintain healthier eating patterns.

When combined with a healthy diet and increased physical activity, MySimba® can support sustainable weight management and long-term lifestyle changes.

Treatment may help to:

• Reduce appetite
• Reduce food cravings
• Improve control over eating habits
• Support calorie reduction
• Promote sustainable weight management

For best results, treatment should be used alongside healthy dietary choices and increased physical activity.

Who May Be Suitable for MySimba®?

You may be suitable for treatment if you:

• Are aged 18 years or over
• Have a Body Mass Index (BMI) of 30+ or 27+ with eligible health conditions
• Are looking for additional support with weight management
• Have found it difficult to achieve sufficient weight loss through lifestyle changes alone

All patients must complete a clinical assessment before treatment can be prescribed.

How to Use MySimba®

MySimba® is taken orally as a prolonged-release tablet.

Treatment is gradually increased over the first four weeks to allow your body to adjust to the medication and help reduce the risk of side effects.

Tablets should be swallowed whole with water and should not be crushed, chewed or split.

Always follow the dosing schedule provided by your clinician and take the medication exactly as prescribed.

Potential Benefits

When prescribed appropriately as part of a comprehensive weight management programme, MySimba® may:

• Support clinically meaningful weight loss
• Help reduce appetite and food cravings
• Improve control over eating behaviours
• Provide a non-injectable treatment option
• Support long-term weight management goals
• Offer ongoing clinician supervision and monitoring

Possible Side Effects

Like all medicines, MySimba® can cause side effects, although not everyone experiences them.

Common side effects may include:

• Nausea
• Constipation
• Headache
• Dizziness
• Dry mouth
• Difficulty sleeping (insomnia)
• Vomiting
• Increased sweating

These effects are often temporary and may improve as your body adjusts to treatment.

Always read the Patient Information Leaflet and consult your healthcare professional if you experience persistent or concerning symptoms.

Frequently Asked Questions

How quickly will I see results?

Weight loss results vary between individuals. Many patients begin to notice changes within the first few weeks when treatment is combined with dietary and lifestyle changes.

Do I need to follow a diet while taking MySimba®?

Yes. MySimba® works best when used alongside a calorie-controlled diet and regular physical activity.

Can I exercise while taking MySimba®?

Yes. Physical activity is encouraged as part of a healthy weight management programme.

What happens if I miss a dose?

Follow the instructions provided in the Patient Information Leaflet or seek advice from your pharmacist or prescriber. Do not take an extra dose to make up for a missed dose.

Do I need a prescription?

No. MySimba® is a Prescription Only Medicine (POM) but doesn’t require a GP prescription. It can be supplied to eligible patients following an assessment by our qualified prescribing clinicians

Our Weight Loss Service

At The Kingston Pharmacy, we provide a personalised, clinician-led weight loss service designed to support you throughout your weight loss journey.

Before treatment can be prescribed, you will complete a confidential online consultation covering your:

• Current weight and height
• Medical history
• Current medications
• Previous weight loss attempts
• Weight management goals

Your consultation will be carefully reviewed by one of our qualified prescribing clinicians, who will assess whether treatment is safe and appropriate for you. If suitable, a personalised treatment plan will be created based on your individual needs and treatment goals.

Flexible Delivery and Collection Options

Once your prescription has been approved, you can choose the option that works best for you:

• Free in-store collection from The Kingston Pharmacy at a time convenient to you.
• Secure home delivery directly to your chosen address, ensuring your medication arrives safely and discreetly.

We aim to make accessing treatment as simple and convenient as possible, allowing you to focus on achieving your weight loss goals.

Ongoing Support Every Step of the Way

Our support doesn’t stop once your medication has been supplied.

As your local community pharmacy, we are committed to providing ongoing guidance throughout your treatment. Whether you have questions about your medication, dosage schedule, side effects, diet, exercise, or your progress, our pharmacy team is here to help.

You can contact us by telephone, email, or by visiting the pharmacy, and we will be happy to answer any questions or address any concerns you may have.

Regular Reviews and Treatment Monitoring

Weight loss treatment is most effective when combined with ongoing monitoring and lifestyle support. As part of our service, we encourage regular reviews to assess your progress, discuss your experience with treatment, and ensure your medication remains appropriate for you.

Our team can provide advice on:

• Healthy eating and nutrition
• Physical activity and exercise
• Managing side effects
• Treatment adherence and dosing schedules
• Maintaining long-term weight loss
• General treatment support and guidance

Important Information

MySimba® is not suitable for everyone and should only be used under appropriate medical supervision.

MySimba® may not be suitable for patients with certain medical conditions, including seizure disorders, uncontrolled high blood pressure, eating disorders, or those taking certain medications. Your clinician will assess your suitability during the consultation process.

Treatment should be combined with healthy dietary changes and increased physical activity. Individual results will vary.

Always use medicines exactly as prescribed.