What is Atovaquone/Proguanil Hydrochloride?
Atovaquone/Proguanil Hydrochloride is a prescription medication used to prevent and treat malaria. It contains a combination of two active ingredients—atovaquone and proguanil—which work together to stop the malaria parasite from multiplying in the body. It is especially effective for travelers visiting malaria-endemic areas.
Who is the ideal candidate for Atovaquone/Proguanil Hydrochloride?
Atovaquone/Proguanil Hydrochloride is suitable for adults and children (above a certain weight) who:
• Are traveling to malaria-risk areas
• Need effective malaria prevention while abroad
• Are in generally good health or have been cleared by a healthcare professional to use malaria prevention treatment
Atovaquone/Proguanil Hydrochloride may not be suitable for individuals who:
• Have a history of severe liver or kidney problems
• Are allergic to any of the ingredients in the medication
• Are pregnant or planning to become pregnant (unless advised by a healthcare professional)
Our trained clinicians will assess your health and travel plans to ensure Atovaquone/Proguanil Hydrochloride is the right choice for you.
How does Atovaquone/Proguanil Hydrochloride work to prevent malaria?
Atovaquone and Proguanil work together to target the malaria parasite. Atovaquone prevents the parasite from reproducing in red blood cells, while Proguanil interferes with the parasite’s ability to divide and multiply. This dual action helps protect you from malaria while traveling to areas where the disease is prevalent.
How do I take Atovaquone/Proguanil Hydrochloride?
Take Atovaquone/Proguanil Hydrochloride daily, starting 1–2 days before entering a malaria-risk area. Continue taking it throughout your stay and for 7 days after leaving the area.
• Swallow the tablet whole with food to help absorption
• Take at the same time each day for consistency
• Don’t skip any doses for maximum effectiveness
Our clinicians will help determine the appropriate dosage based on your weight, health status, and travel plans.
What are the main side effects of Atovaquone/Proguanil Hydrochloride?
Like all medications, Atovaquone/Proguanil Hydrochloride can cause side effects, though not everyone will experience them. Common side effects include:
• Nausea or stomach upset
• Diarrhea
• Headache
• Dizziness
• Insomnia or vivid dreams
These side effects are generally mild and go away on their own. However, if you experience any severe reactions or allergic symptoms, contact a healthcare professional immediately.
Will Atovaquone/Proguanil Hydrochloride cure malaria?
No, Atovaquone/Proguanil Hydrochloride is a preventive treatment and does not cure malaria. If you contract malaria, different medications will be required for treatment.
Is Atovaquone/Proguanil Hydrochloride the same as Malarone?
Yes, Atovaquone/Proguanil Hydrochloride is the generic version of Malarone. Both contain the same active ingredients—atovaquone and proguanil—used to prevent and treat malaria.
What else should I know about Atovaquone/Proguanil Hydrochloride?
• Start taking Atovaquone/Proguanil Hydrochloride before traveling to malaria-endemic areas for effective prevention
• Don’t skip doses—consistent use is key to protecting against malaria
• Ensure you take the medication with food for best absorption
• Be honest in your medical questionnaire so we can ensure the medication is safe for you
Where can I get Atovaquone/Proguanil Hydrochloride for malaria prevention?
Getting started is easy. Simply complete our short online medical questionnaire. One of our experienced clinicians will review your health and travel plans to ensure Atovaquone/Proguanil Hydrochloride is safe and effective for your needs. If approved, we’ll deliver your medication straight to your door or have it ready for pickup at The Kingston Pharmacy.




